Depo-Provera and Sayana Press contain the same active ingredient - a progestogen hormone - at the same dose. They are similar in price and both last for 13 weeks.
The difference between them is the shape of the syringe. Sayana Press has a syringe that can easily be pressed to inject the medicine - hence its name. It is easy to use by the woman on herself at home. Depo-Provera has a normal syringe with a plunger and should be administered by a healthcare professional.